DNA sequence analysis of DNA gyrase and DNA topoisomerase IV quinolone resistance-determining regions of Salmonella enterica serovar Typhi and serovar Paratyphi A.

نویسندگان

  • Kenji Hirose
  • Ai Hashimoto
  • Kazumichi Tamura
  • Yoshiaki Kawamura
  • Takayuki Ezaki
  • Hiroko Sagara
  • Haruo Watanabe
چکیده

The mutations that are responsible for fluoroquinolone resistance in the gyrA, gyrB, parC, and parE genes of Salmonella enterica serovar Typhi and serovar Paratyphi A were investigated. The sequences of the quinolone resistance-determining region of the gyrA gene in clinical isolates which showed decreased susceptibilities to fluoroquinolones had a single mutation at either the Ser-83 or the Asp-87 codon, and no mutations were found in the gyrB, parC, and parE genes.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 46 10  شماره 

صفحات  -

تاریخ انتشار 2002